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The Python is an Ultimate weapon inThe First Descendantthat stands out for its ability to debuff enemy defense and toxic resistance, making it useful against high-health targets, especially Colossi. However, its unique ability triggers only when hitting enemy Weak Points, so it’s most effective in focused battles rather than against swarms of Vulguses.
But if you want to harness the true power of this Ultimate weapon, you’ll need to put in a lot of attention to details, especially on the modules you equip on it. To help you maximize the DPS and get the most value, here’s a complete breakdown of how you should build the Python inThe First Descendant.
What is Python in The First Descendant?
The Python is the Ultimate Weapon inThe First Descendant,and is asubmachine-gunwith a unique ability called thePython Instinct. When you hit an enemy’s Weak Point, you trigger the Prey status, whichreduces the target’s DEF and Toxic Resistance by 10 percent. This makes Python particularly effective against Colossi and enemies with high resistance. Pythonexcels in single-target combatbut struggles with crowd control due to its Weak Point dependency. Here are the base stats of the Python weapon to help you get a better idea of this weapon’s abilities:
21
923
30
1.5 seconds
5%
1.3x
3.45%
Weak Point Damage
2x
Though the Python’s debuff benefits every Descendant, it’s especially effective forpoison-focused characters like Freyna, who can capitalize on the lowered Toxic Resistance to further enhance her poison damage. It’s also aviable option for Ajax, given his tanky nature and high defense stats.
Effect
Have Aiming
Increases Weak Point Damage by 10%, though it slightly reduces accuracy.
Action and Reaction
Boosts a flat DPS increase from Firearm ATK by 15% and increases recoil by 5%, overall enhancing the damage output.
Rifling Reinforcement
Adds 12% Explosive ATK, making it a solid choice for increasing overall effectiveness.
Weak Point Sight
Boosts Weak Point Damage by an additional 9%, helping you maximize the weapon’s DPS against single targets.
In the early game, Python’s main role is to help you deal explosive damage to single target Vulguses, especiallyWeak Point targeting and exploiting the Prey debuffagainst bosses.Firearm ATK and Weak Point Damageare the essential modules for the early game build.
These modules focus on increasing the Weak Point damage to maximize Python’s potential, making itdeadly against bosses and Colossi. You’ll have your weak point damageincreased by almost 20 percent, which makes the damage numbers close to2.5 times the base damage.
Poison Priority
Increases Toxic ATK by 13% and reduces reload time by 8%, making it ideal against electric-type Vulguses and even Colossi.
Fixed Shot
Reduces recoil by 8% and increases Weak Point damage by 2%, further bolstering the weakpoint damage and also providing stability.
Mental Focus
Reduces fire rate by 10%, but provides increased Firearm ATK. It helps balance Python’s fast-firing with substantial damage boosts.
Weak Point Aiming
Increases accuracy and weak point damage by 8% and 2%, respectively.
Toxic Enhancement
Adds Toxic ATK equal to 8% of Firearm ATK, increasing Python’s synergy with Toxic builds.
In the late game, the Python’s potential skyrockets, especiallyagainst high-level Colossus enemies. To truly unlock its power, your build should focus on boosting its already high Weak Point damage and enhancing Toxic resistance debuffs, turning Python into a DPS machine that canshred through boss and elite encounters.
With the above build, the Python becomes a high-damage, precise weapon because ofFixed Shot and Mental Focusthat is capable of dealing with even the toughest Colossi, especially when used bycharacters like Freyna, who can capitalize on the enhanced Toxic damage.
Boosts Weak Point Damage, boosting DPS to clear mobs quicker.
A flat 15% boost to Firearm ATK increases DPS even more.
Fire Rate UP
Increasing the fire rate by 6% is essential for farming, as it increases the efficiency of clearing mobs significantly.
Increases the Weak Point Damage output even more to help deal with occasional elite Vulguses.
When farming inThe First Descendant, having a high fire rate and even higher DPS is essential. In such cases, Python can be a good choice for farming high-value resources, especially inregions dominated by electric-type enemieslike Hagios or Kingston. With the above build, you may easily farm resources in most regions with ease,even on hard difficulty.
If you’re struggling in any of the regions on Hard difficulty, upgrading your module level is enough to clear them eventually.
Increases Toxic ATK by 13% and reduces reload time by 8%, making it ideal against electric-type Colossi.
Reduces recoil by 8% and increases Weak Point damage by 2%, increasing the weakpoint damage and providing stability.
Reduces fire rate by 10%, but provides increased Firearm ATK, which means more DPS.
Explosive ATK boost adds a little extra punch espeically if you don’t have type-advantage.
Void Intercept battles require high-impact weapons and Python isone of the few Ultimate Weaponsthat shine in this game mode. As it can inflict debuffs on the defense and Toxic resistance, it isparticularly effective against solo bosses.
Your focus should be on maximizing damage by ensuring you consistently hit the Weak Points of the colossi. This build turns Python into an ideal weapon for shredding down Void Intercept bosses,especially the likes of Executioner, Devourer and the Hanged Manbecause of the additional type advantage.
